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Ethanol,2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]- (101622-51-9)

Identification
Name:Ethanol,2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
Synonyms:2-(2-Hydroxyethylamino)-6-(benzylamino)-9-methylpurine;2-(2'-Hydroxyethylamino)-9-methyl-6-(benzylamino)purine;6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine;NSC 666096;
CAS:101622-51-9
Molecular Formula: C15H18N6O
Molecular Weight: 298.34302
InChI: InChI=1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)
Molecular Structure: (C15H18N6O) 2-(2-Hydroxyethylamino)-6-(benzylamino)-9-methylpurine;2-(2'-Hydroxyethylamino)-9-methyl-6-(benzylam...
Properties
Transport:HAZARD
Density:1.36 g/cm3
Refractive index:1.69
Water Solubility:Insoluble (soluble in methanol, DMSO
Solubility:Insoluble (soluble in methanol, DMSO
Appearance:white crystalline powder
Specification:

1.General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
2.Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. 
3.Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
4.Storage: Store Olomoucin (CAS NO. 101622-51-9) in a cool, dry place. Store in a tightly closed container. Deep freeze (below -20°C).

Biological Activity: Cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase. Selectively inhibits cdc2/cyclin B (IC 50 = 7 μ M), cdk2/cyclin A (IC 50 = 7 μ M), cdk2/cyclin E (IC 50 = 7 μ M), cdk/p35 kinase (IC 50 = 3 μ M)? and ERK1/MAP kinase (IC 50 = 25 μ M). Arrests human fibroblasts in the G1 phase.
Storage Temperature: −20°C
Usage:

Olomoucin (CAS NO. 101622-51-9) is a purine derivative which inhibits cyclin-dependent kinases and induces G1 arrest .

Safety Data
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