| Identification | |
| Name: | Benzamide,N-[4-oxo-2-(2H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)- |
| Synonyms: | Benzamide,N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)- (9CI);4-Oxo-8-[4-(4-phenylbutoxy)benzoylamino]-2-(tetrazol-5-yl)-4H-1-benzopyran;8-[4-(4-Phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran;Azlaire;CCN 00401;ONO 1078;ONO-RS 411;Onon;RS 411;SB 205312; |
| CAS: | 103177-37-3 |
| EINECS: | 201-616-4 |
| Molecular Formula: | C27H23N5O4 |
| Molecular Weight: | 481.5 |
| InChI: | InChI=1/C27H23N5O4/c33-23-17-25(26-29-31-32-30-26)36-24-16-20(11-14-22(23)24)28-27(34)19-9-12-21(13-10-19)35-15-5-4-8-18-6-2-1-3-7-18/h1-3,6-7,9-14,16-17H,4-5,8,15H2,(H,28,34)(H,29,30,31,32) |
| Molecular Structure: | ![(C27H23N5O4) Benzamide,N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)- (9CI);4-Oxo-8-[4-(...](https://img.guidechem.com/casimg/103177-37-3.gif) |
| Properties | |
| Density: | 1.374g/cm3 |
| Refractive index: | 1.68 |
| Appearance: | off-white solid |
| Specification: |
?Pranlukast ,its CAS NO. is 103177-37-3,the synonyms is 4-Oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4h-1-benzopyranh ; Benzamide,n-(4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-4-phenylbutox;emihydrate ; Hemihydrate ; n-(4-Oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzam ; Ono1078 ; Rs411 . |
| Biological Activity: | Selective cysteinyl leukotriene receptor 1 (CysLT 1 ) antagonist (IC 50 values are ~ 4-7 and 3620 nM for CysLT 1 and CysLT 2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma. |
| Usage: | A potent, selective and orally active CysLT receptor antagonist. Leukotriene antagonist. Used as an antiasthmatic |
| Safety Data | |
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