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Colistin (1066-17-7)

Identification
Name:Colistin
Synonyms:Colimycin;Colisticina;Colivet;Coly-Mycin;Kangdisu;Polymyxin E;Totazina;
CAS:1066-17-7
EINECS: 213-907-3
Molecular Formula: C52H98N16O13
Molecular Weight: 1155.43
InChI: InChI=1/C53H100N16O13/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+/m1/s1
Molecular Structure: (C52H98N16O13) Colimycin;Colisticina;Colivet;Coly-Mycin;Kangdisu;Polymyxin E;Totazina;
Properties
Transport:3249
Flash Point: 883.3°C
Boiling Point: 1536.8°Cat760mmHg
Density:1.25g/cm3
Refractive index:1.573
Specification:

Colistin (polymyxin E) is a polymyxin antibiotic produced by certain strains of Bacillus polymyxa var. colistinus. Colistin is a mixture of cyclic polypeptides colistin A and B.
Adverse reactions of Polymyxin E (1066-17-7):
The main toxicities described with intravenous treatment are nephrotoxicity (damage to the kidneys) and neurotoxicity (damage to the nerves), but this may reflect the very high doses given, which are much higher than the doses currently recommended by any manufacturer and for which no adjustment was made for renal disease. Neuro- and nephrotoxic effects appear to be transient and subside on discontinuation of therapy or reduction in dose.
At a dose of 160mg colistimethate IV every eight hours, very little nephrotoxicity is seen. Indeed, colistin appears to have less toxicity than the aminoglycosides that subsequently replaced it, and colistin has been used for extended periods of up to six months with no ill effects.
The main toxicity described with aerosolised treatment is bronchospasm  which can be treated or prevented with the use of beta2-agonists such as salbutamol or following a desensitisation protocol.

Report:

EPA Genetic Toxicology Program.

Packinggroup: III
Flash Point: 883.3°C
Safety Data
 

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