| Identification |
| Name: | 1H-Indole-2-carboxylicacid, 5-chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)- |
| Synonyms: | nTZDpa |
| CAS: | 118414-59-8 |
| Molecular Formula: | C22H15 Cl2 N O2 S |
| Molecular Weight: | 428.33 |
| InChI: | InChI=1/C22H15Cl2NO2S/c23-15-8-6-14(7-9-15)13-25-19-11-10-16(24)12-18(19)21(20(25)22(26)27)28-17-4-2-1-3-5-17/h1-12H,13H2,(H,26,27) |
| Molecular Structure: |
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| Properties |
| Flash Point: | 334.2°C |
| Boiling Point: | 628.9°Cat760mmHg |
| Density: | 1.37g/cm3 |
| Refractive index: | 1.672 |
| Biological Activity: | Potent, selective non-thiazolidinedione PPAR γ partial agonist (EC 50 = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC 50 ~ 285 nM). Displays no activity at PPAR α or PPAR δ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPAR γ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo . |
| Flash Point: | 334.2°C |
| Safety Data |
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