| Identification | |
| Name: | Anastrozole |
| Synonyms: | 10-Methoxy-5H-dibenz[b,f]azepine-5-carbonylchloride;1,3-Benzenediacetonitrile,a,a,a',a'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)- (9CI);2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile);2-[3-(2-Cyano-2-propyl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropiononitrile;Asiolex;Anastrol; |
| CAS: | 120511-73-1 |
| Molecular Formula: | C17H19N5 |
| Molecular Weight: | 293.37 |
| InChI: | InChI=1/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3 |
| Molecular Structure: | ![(C17H19N5) 10-Methoxy-5H-dibenz[b,f]azepine-5-carbonylchloride;1,3-Benzenediacetonitrile,a,a,a',a'-tetramethyl-...](https://img.guidechem.com/casimg/120511-73-1.gif) |
| Properties | |
| Transport: | OTH |
| Flash Point: | 469.7 oC at 760 mmHg |
| Density: | 1.08 g/cm3 |
| Refractive index: | 1.791 |
| Solubility: | Insoluble |
| Appearance: | crystalline solid |
| Specification: | Anastrozole (CAS NO.120511-73-1), its Synonyms are Arimidex ; Asiolex ; alpha,alpha,alpha',alpha'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile ; 1,3-Benzenediacetonitrile, alpha,alpha,alpha',alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)- . It is crystalline solid. |
| Packinggroup: | III |
| Biological Activity: | Potent and highly selective aromatase (CYP19) inhibitor (IC 50 = 5nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo. Orally active. |
| Flash Point: | 469.7 oC at 760 mmHg |
| Storage Temperature: | Store in original container in a cool dark place. |
| Color: | Crystals from ethyl acetate/cyclohexane Off-white powder |
| Usage: | An aromatase inhibitor. Used as an antineoplastic. |
| Safety Data | |
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