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Gemcitabine hydrochloride (122111-03-9)

Identification
Name:Gemcitabine hydrochloride
Synonyms:Gemcitabine HCl;2',2'-Difluorodeoxycytidine monohydrochloride;2'-Deoxy-2',2'-difluorocytidine monohydrochloride;2'-Deoxy-2',2'-difluorocytidine monohydrochloride (beta-isomer);
CAS:122111-03-9
Molecular Formula: C9H11F2N3O4.HCl
Molecular Weight: 299.66
InChI: InChI=1/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1
Molecular Structure: (C9H11F2N3O4.HCl) Gemcitabine HCl;2',2'-Difluorodeoxycytidine monohydrochloride;2'-Deoxy-2',2'-difluorocytidine monohy...
Properties
Density:==
Solubility:In water, 5.13X10+4 mg/L at 25 deg C (est)
Appearance:White crystalline granular, odorless
Biological Activity: Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitro and in vivo .
Color: Crystals from water, pH = 8.5
Usage:

An antineoplastic

Safety Data
Hazard Symbols Xi: Irritant