| Identification |
| Name: | 9(10H)-Anthracenone,10,10-bis(4-pyridinylmethyl)- |
| Synonyms: | DR 960418;XE 991 |
| CAS: | 122955-42-4 |
| Molecular Formula: | C26H20 N2 O |
| Molecular Weight: | 451.39 |
| InChI: | InChI=1/C26H20N2O.2ClH/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25;;/h1-16H,17-18H2;2*1H |
| Molecular Structure: |
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| Properties |
| Flash Point: | 332°C |
| Boiling Point: | 625.3°Cat760mmHg |
| Density: | g/cm3 |
| Biological Activity: | Potent and selective blocker of KCNQ voltage-gated potassium channels. Blocks KCNQ2+3/M-currents (IC 50 = 0.6-0.98 μ M) and KCNQ1 homomeric channels (IC 50 = 0.75 μ M) but is less potent against KCNQ1/minK channels (IC 50 = 11.1 μ M). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo . |
| Flash Point: | 332°C |
| Safety Data |
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