| Identification |
| Name: | KN 62 |
| Synonyms: | 5-Isoquinolinesulfonicacid,4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenylester, (S)-;5-Isoquinolinesulfonicacid,4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenylester; |
| CAS: | 127191-97-3 |
| Molecular Formula: | C38H35N5O6S2 |
| Molecular Weight: | 721.8444 |
| InChI: | InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3 |
| Molecular Structure: |
![(C38H35N5O6S2) 5-Isoquinolinesulfonicacid,4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazin...](https://img1.guidechem.com/chem/e/dict/15/127191-97-3.jpg) |
| Properties |
| Density: | 1.388 g/cm3 |
| Refractive index: | 1.685 |
| Appearance: | white solid |
| Biological Activity: | Selective, cell-permeable inhibitor of CaM kinase II (IC 50 = 0.9 μ M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X 7 receptor (IC 50 = 15 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ . |
| Storage Temperature: | −20°C |
| Color: | white |
| Usage: | A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II |
| Safety Data |
| |
 |
