| Identification |
| Name: | 2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)- |
| Synonyms: | (2E)-3-(3,4-Dihydroxyphenyl)-2-cyano-N-benzylprop-2-enamide; |
| CAS: | 134036-52-5 |
| Molecular Formula: | C17H14N2O3 |
| Molecular Weight: | 294.3 |
| Molecular Structure: |
 |
| Properties |
| Melting Point: | 215ºC |
| Flash Point: | 325.9°C |
| Boiling Point: | 615.2°Cat760mmHg |
| Density: | 1.337g/cm3 |
| Water Solubility: | Soluble in ethanol: 5 mg/mL |
| Solubility: | Soluble in ethanol: 5 mg/mL |
| Appearance: | yellow solid |
| Flash Point: | 325.9°C |
| Storage Temperature: | −20°C |
| Color: | yellow |
| Usage: | A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not signific |
| Safety Data |
| Hazard Symbols |
Xi: Irritant
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