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1H-Pyrrole-2-carboxamide,4-[[2-[(aminoiminomethyl)amino]acetyl]amino]-N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-1-methyl- (1438-30-8)

Identification
Name:1H-Pyrrole-2-carboxamide,4-[[2-[(aminoiminomethyl)amino]acetyl]amino]-N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-1-methyl-
Synonyms:1H-Pyrrole-2-carboxamide,4-[[[(aminoiminomethyl)amino]acetyl]amino]-N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-1-methyl-(9CI); Congocidine (6CI); N,4'-Bi[pyrrole-2-carboxamide],N'-(2-amidinoethyl)-4-(2-guanidinoacetamido)-1,1'-dimethyl- (7CI,8CI);Congocidin; IA 887; NCI 3067; NSC 3067; Netropsin; Sinanomycin; T 1384
CAS:1438-30-8
Molecular Formula: C18H26 N10 O3
Molecular Weight: 430.54
InChI: InChI=1/C18H26N10O3.2ClH/c1-27-8-11(16(30)23-4-3-14(19)20)12(9-27)26-17(31)13-5-10(7-28(13)2)25-15(29)6-24-18(21)22;;/h5,7-9H,3-4,6H2,1-2H3,(H3,19,20)(H,23,30)(H,25,29)(H,26,31)(H4,21,22,24);2*1H
Molecular Structure: (C18H26N10O3) 1H-Pyrrole-2-carboxamide,4-[[[(aminoiminomethyl)amino]acetyl]amino]-N-[5-[[(3-amino-3-iminopropyl)am...
Properties
Transport:UN 2811 6.1/PG 3
Flash Point: °C
Boiling Point: °Cat760mmHg
Density:1.52g/cm3
Specification:

  Netropsin with CAS number of 1438-30-8 is also known as 2814-A ; 4-22-00-06712 (Beilstein Handbook Reference) ; Antibiotic 1142 ; Antibiotic T-1384 ; BRN 0376913 ; CH-777-A ; Congocidin ; Congocidine ; Netropsin ; Sinanomycin .It shoud be storaged at −20°C. Netropsin binds to the minor groove of AT-rich sequences of double stranded DNA . In contrast, Netropsin does not bind single stranded DNA or double stranded RNA. Crystallographic structures of DNA-bound Netropsin have been obtained and elucidate details of how the drug binds in the minor groove . In the bound structure, the drug makes hydrogen bonding interactions with four subsequent base pairs of the DNA duplex, locally displacing the water molecules of the spine of hydration. It has been shown that Netropsin is active both against Gram-positive bacteria and Gram-negative bacteria.

Flash Point: °C
Storage Temperature: −20°C
Color: faint yellow
Safety Data
Hazard Symbols Xn: Harmful
 

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