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1,6-Naphthyridin-2(1H)-one,5,7-diethyl-3,4-dihydro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-,hydrochloride (1:1) (146709-78-6)

Identification
Name:1,6-Naphthyridin-2(1H)-one,5,7-diethyl-3,4-dihydro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-,hydrochloride (1:1)
Synonyms:1,6-Naphthyridin-2(1H)-one,5,7-diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-,monohydrochloride (9CI); ZD 7155
CAS:146709-78-6
Molecular Formula: C26H26 N6 O . Cl H
Molecular Weight: 474.99
InChI: InChI=1/C26H26N6O.ClH/c1-3-19-15-24-22(23(4-2)27-19)13-14-25(33)32(24)16-17-9-11-18(12-10-17)20-7-5-6-8-21(20)26-28-30-31-29-26;/h5-12,15H,3-4,13-14,16H2,1-2H3,(H,28,29,30,31);1H
Molecular Structure: (C26H26N6O.ClH) 1,6-Naphthyridin-2(1H)-one,5,7-diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]met...
Properties
Flash Point: 405.2°C
Boiling Point: 746.4°Cat760mmHg
Density:g/cm3
Biological Activity: A potent and selective competitive antagonist for the angiotensin II type 1 (AT 1 ) receptor. Displaces [ 125 I]-angiotensin II binding with an IC 50 value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT 1 antagonist, losartan.
Flash Point: 405.2°C
Safety Data
 

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