| Identification | |
| Name: | Carmustin |
| Synonyms: | Urea,1,3-bis(2-chloroethyl)-1-nitroso- (8CI);1,3-Bis(b-chloroethyl)-1-nitrosourea;BCNU;Becenun;BiCNU;DTI 015;FDA 0345;Gliadel;Gliadel Wafer;N,N'-Bis(2-chloroethyl)-N-nitrosourea;NSC 409962;Nitrumon;SK 27702;SRI 1720; |
| CAS: | 154-93-8 |
| EINECS: | 205-838-2 |
| Molecular Formula: | C5H9Cl2N3O2 |
| Molecular Weight: | 214.05 |
| InChI: | InChI=1/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11) |
| Molecular Structure: |  |
| Properties | |
| Transport: | 3249 |
| Boiling Point: | 404 |
| Density: | 1.46 g/ml |
| Stability: | No data. |
| Refractive index: | 1.548 |
| Solubility: | <0.1 g/100 mL at 18 oC |
| Appearance: | Orange-yellow solid. |
| Specification: |
?Carmustin, its CAS NO. is 154-93-8, the synonyms are 1,3-Bis(2-chloroethyl)-1-nitrosourea ; 1,3-Bis(2-chloroethyl)nitrosourea ; 1,3-Bis(beta-chloroethyl)-1-nitrosourea ; Bis(2-chloroethyl)1-nitrosourea ; Bis(2-chloroethyl)nitrosourea ; Bis-N,N'-(chloroethyl)nitrosourea ; Bischlorethylnitrosourea ; Bischlorethylnitrosurea ; Bischloroethyl nitrosourea ; Bischloroethylnitrosourea . |
| Report: |
NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2A IMEMDT ?? IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man 7 (1987),p. 150.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.:?) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT ?? IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man 26 (1981),p. 79.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.:?) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT ?? IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man 26 (1981),p. 79.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.:?) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Studies (ipr); Some Evidence: rat CANCAR ?? Cancer. 40 (1977),1935. ; Clear Evidence: mouse CANCAR ?? Cancer. 40 (1977),1935. . EPA Genetic Toxicology Program. |
| Packinggroup: | II |
| Color: | Light yellow powder Light yellow powder that melts to an oily liquid |
| Usage: | An alkylating and carbamoylating nitrosourea compound. It interacts with DNA, RNA and proteins causing DNA interstrand cross linking which is cytotoxic and leads to apoptotic cell death |
| Safety Data | |
| Hazard Symbols |
T+:Verytoxic
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