| Identification | |
| Name: | Tetradecanoic acid,(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-ylester |
| Synonyms: | Myristicacid, 9-ester with 1,1aa,1bb,4,4a,7aa,7b,8,9,9a-decahydro-4ab,7ba,9b,9aa-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8a-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one9a-acetate, (+)- (8CI); Tetradecanoic acid,9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-ylester, [1aR-(1aa,1bb,4ab,7aa,7ba,8a,9b,9aa)]-;1H-Cyclopropa[3,4]benz[1,2-e]azulene, tetradecanoic acid deriv.;12-O-Tetradecanoylphorbol 13-acetate; 12-Tetradecanoylphorbol 13-acetate;12-Tetradecanoylphorbol 13-monoacetate; 13-O-Acetylphorbol 12-myristate; 4b-Phorbol 12-myristate 13-acetate;Factor A1; Factor A1 (croton oil); NSC 262244; PMA; PMA (tumor promoter);Phorbol 12-myristate 13-acetate; Phorbol 12-tetradecanoate 13-acetate; Phorbolmyristate acetate; TPA; TPA (phorbol derivative); b-Phorbol 12-myristate 13-acetate |
| CAS: | 16561-29-8 |
| EINECS: | 16561-29-8 |
| Molecular Formula: | C36H56 O8 |
| Molecular Weight: | 616.82504 |
| InChI: | InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1 |
| Molecular Structure: |  |
| Properties | |
| Transport: | 2928 |
| Density: | 1.17 g/cm3 |
| Refractive index: | 1.553 |
| Water Solubility: | Soluble in DMSO, methanol, 100% ethanol, acetone, ether or dimethylformamide; almost insoluble in aqueous buffers. |
| Solubility: | Soluble in DMSO, methanol, 100% ethanol, acetone, ether or dimethylformamide; almost insoluble in aqueous buffers. |
| Appearance: | White to off-white solid. |
| Specification: |
Phorbol myristate acetate (CAS NO.16561-29-8), its Synonyms are Tetradecanoylphorbol acetate ; 12-O-Tetradecanoyl phorbol acetate ; 12-O-Tetradecanoylphorbol 13-acetate ; 12-O-Tetradecanoylphorbol-13-acetate ; 13-O-Acetylphorbol 12-myristate ; 13-Tetradecanoylphorbol acetate ; 4beta-Phorbol 12-myristate 13-acetate . It is white to off-white solid. |
| Report: |
EPA Genetic Toxicology Program. |
| Packinggroup: | II |
| Biological Activity: | Extensively used phorbol ester activator of protein kinase C; tumor promoter. Binds to PKC with a K i value of 2.6 nM as measured by displacement of [ 3 H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes. |
| Storage Temperature: | −20°C |
| Safety Data | |
| Hazard Symbols |
Xi: Irritant
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