L-a-Asparagine, N-acetyl-L-a-aspartyl-L-a-glutamyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- (169332-61-0)

Identification
Name:	L-a-Asparagine, N-acetyl-L-a-aspartyl-L-a-glutamyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
Synonyms:	L-a-Asparagine,N2-[N-[N-(N-acetyl-L-a-aspartyl)-L-a-glutamyl]-L-valyl]-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
CAS:	169332-61-0
Molecular Formula:	C30H37 N5 O13
Molecular Weight:	675.64
Molecular Structure:
Properties
Density:	1.423 g/cm³
Water Solubility:	DMSO: 10 mM
Solubility:	DMSO: 10 mM
Appearance:	white powder
Specification:	Ac-DEVD-AMC (CAS NO.169332-61-0) is a synthetic tetrapeptide fluorogenic substrate for Caspase-3 (CPP32) and contains the amino acid sequence of the PARP cleavage site at Asp-216. The tetrapeptide substrate can be used to identify and quantify the Caspase-3 activity in apoptotic cells. Caspase-3 cleaves the tetrapeptide between D and AMC, thus releasing the fluorogenic AMC, which can be quantified in a spectrofluorometer. The substrate can also be used to study the inhibition of Caspase-3 by the tetrapeptide aldehyde, Ac-DEVD-CHO or any other inhibitor of Caspase-3.
Safety Data