| Identification |
| Name: | Piperazine,1-cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]- |
| Synonyms: | PB 28 |
| CAS: | 172906-90-0 |
| Molecular Formula: | C24H38 N2 O |
| Molecular Weight: | 0 |
| InChI: | InChI=1/C24H38N2O.2ClH/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21;;/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3;2*1H |
| Molecular Structure: |
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| Properties |
| Biological Activity: | High affinity σ 2 receptor agonist (K i values are 0.8 and 15.2 nM for σ 2 and σ 1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC 50 values are 2.62 and 3.96 μ M respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells. |
| Safety Data |
| Hazard Symbols |
Xi: Irritant
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