| Identification |
| Name: | Tecalcet hydrochloride [USAN] |
| Synonyms: | 2-Chloro-N-[(1R)-1-(3-methoxyphenyl
)ethyl]-benzenepropanamine hydrochloride |
| CAS: | 177172-49-5 |
| Molecular Formula: | C18H23Cl2NO |
| Molecular Weight: | 340.29 |
| InChI: | InChI=1/C18H22ClNO.ClH/c1-14(16-8-5-10-17(13-16)21-2)20-12-6-9-15-7-3-4-11-18(15)19;/h3-5,7-8,10-11,13-14,20H,6,9,12H2,1-2H3;1H/t14-;/m1./s1 |
| Molecular Structure: |
![(C18H23Cl2NO) 2-Chloro-N-[(1R)-1-(3-methoxyphenyl )ethyl]-benzenepropanamine hydrochloride](https://img.guidechem.com/newimg/177172-49-5.png) |
| Properties |
| Flash Point: | 205.6°C |
| Boiling Point: | 416.3°C at 760 mmHg |
| Solubility: | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| Biological Activity: | Positive allosteric modulator and allosteric agonist of the human calcium-sensing receptor (hCaSR). Exhibits calcimimetic activity. Has the ability to restore function to hCaSR mutants that cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT). Exerts a suppressive effect on parathyroid (PT) hormone secretion; inhibits PT cell proliferation in rats with renal insufficiency. |
| Flash Point: | 205.6°C |
| Storage Temperature: | Desiccate at RT |
| Safety Data |
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