| Identification |
| Name: | 1H-Pyrazole-3-carboxamide,1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl- |
| Synonyms: | AM 251;AM251 (pharmaceutical); |
| CAS: | 183232-66-8 |
| Molecular Formula: | C22H21Cl2IN4O |
| Molecular Weight: | 555.23881 |
| InChI: | InChI=1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30) |
| Molecular Structure: |
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| Properties |
| Flash Point: | °C |
| Boiling Point: | °Cat760mmHg |
| Density: | 1.65 g/cm3 |
| Refractive index: | 1.702 |
| Water Solubility: | Insoluble at 25.0 C,PBS 7.2, sol. in EtOH, DMF, & DMSO |
| Solubility: | Insoluble at 25.0 C,PBS 7.2, sol. in EtOH, DMF, & DMSO |
| Appearance: | A crystalline solid |
| Biological Activity: | Potent CB 1 receptor antagonist (IC 50 = 8 nM, K i = 7.49 nM) that displays 306-fold selectivity over CB 2 receptors. Also potent GPR55 agonist (EC 50 = 39 nM). Also available as part of the Cannabinoid CB 1 Receptor Tocriset™ . |
| Flash Point: | °C |
| Color: | white |
| Usage: | Inhibitor of CB1 receptors. |
| Safety Data |
| Hazard Symbols |
Xi: Irritant
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