| Identification | |
| Name: | Gefitinib |
| Synonyms: | N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;ZD1839;4-(3-Chloro-4-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline;Irressat;Gefitinib (JAN/USAN);4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-;ZD 1839;4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-; |
| CAS: | 184475-35-2 |
| Molecular Formula: | C22H24ClFN4O3 |
| Molecular Weight: | 446.9 |
| InChI: | InChI=1/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) |
| Molecular Structure: |  |
| Properties | |
| Melting Point: | 119-120 |
| Density: | 1.322g/cm3 |
| Refractive index: | 1.621 |
| Appearance: | Light-Yellow Crystalline Powder |
| Specification: |
? Gefitinib ,?its cas register number is 184475-35-2. It also can be called?4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline ; CCRIS 9011 ; Iressa ; Irressat .?Gefitinib (CAS NO.184475-35-2) is?an light-yellow crystalline Powder. |
| Biological Activity: | Orally active, selective inhibitor of EGFR tyrosine kinase (IC 50 = 23-79 nM). Shows minimal activity against ErbB2, KDR, c-flt, PKC, MEK and ERK-2. Blocks EGFR autophosphorylation and inhibits tumor growth in mice bearing a range of human xenografts. |
| Usage: | An antineoplastic |
| Safety Data | |
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