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10H-Phenoxazine-10-butanamine,2-chloro-N,N-diethyl- (201788-90-1)

Identification
Name:10H-Phenoxazine-10-butanamine,2-chloro-N,N-diethyl-
Synonyms:10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine
CAS:201788-90-1
Molecular Formula: C20H25 Cl N2 O
Molecular Weight: 0
InChI: InChI=1/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23;/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3;1H
Molecular Structure: (C20H25ClN2O) 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine
Properties
Flash Point: 250.7°C
Boiling Point: 490.9°Cat760mmHg
Density:g/cm3
Biological Activity: Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μ M), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC 50 ~ 2-6 μ M) and induces apoptosis in rhabdomyosarcoma cells.
Flash Point: 250.7°C
Safety Data
 

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