InChI: | InChI=1/C25H29F2N5O3.C2HF3O2/c1-35-24(34)20(10-6-12-30-25(28)29)31-21(33)11-5-9-17-18-13-16(26)14-19(27)23(18)32-22(17)15-7-3-2-4-8-15;3-2(4,5)1(6)7/h2-4,7-8,13-14,20,32H,5-6,9-12H2,1H3,(H,31,33)(H4,28,29,30);(H,6,7)/t20-;/m0./s1 |
Biological Activity: | Potent and selective somatostatin sst 4 receptor agonist. K i values are 0.7, 199, 4720, 1280 and 3880 nM for cloned human sst 4 , sst 1 , sst 2 , sst 3 and sst 5 receptors respectively. Facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice in vivo . |