2,4-Thiazolidinedione,3-[1-[[(3'-nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]- (227088-94-0)

Identification
Name:	2,4-Thiazolidinedione,3-[1-[[(3'-nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-
Synonyms:	AZ 11645373
CAS:	227088-94-0
Molecular Formula:	C24H21 N3 O5 S
Molecular Weight:	0
Molecular Structure:
Properties
Biological Activity:	Potent and selective human P2X 7 antagonist (K B values are 5 - 7 and > 10,000 nM at hP2X 7 and rP2X 7 respectively) that is completely without effect at all other P2X subtypes. Inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1 β release in vitro (K B values are 15 and 92 nM respectively).
Storage Temperature:	2-8°C
Safety Data
Hazard Symbols	Xi: Irritant

Other Product

1,2-Benzenedimethanol,4-[[[4'-(1-ethyl-1-hydroxypropyl)-6-methyl-2'-propyl[1,1'-biphenyl]-3-yl]oxy]methyl]-
Ethanone, 1-(3-hydroxy-4'-nitro-2-propyl[1,1'-biphenyl]-4-yl)-
1,2-Benzenedimethanol,4-[[[6-ethyl-4'-(1-ethyl-1-hydroxypropyl)-2'-propyl[1,1'-biphenyl]-3-yl]oxy]methyl]-
Morpholine,4-[3-[[1-methyl-3-propyl-4-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-pyrazol-5-yl]oxy]-1-oxopropyl]-
2H-1-Benzopyran-3-carboxylic acid,2-oxo-7-[[(4'-propyl[1,1'-biphenyl]-4-yl)carbonyl]oxy]-, methyl ester
2,4-Thiazolidinedione,3-[(4-fluorophenyl)methyl]-5-[[1-(2-propenyl)-1H-indol-3-yl]methylene]-(9CI)
Propanoic acid,2-methyl-2-[[2-methyl-1-propyl-3-(4-pyridinyl)-1H-indol-5-yl]oxy]-,hydrochloride (1:?)
Piperazine,1-(2-methoxyphenyl)-4-[[[1-methyl-3-propyl-4-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-pyrazol-5-yl]oxy]acetyl]-
Piperazine,1-(2-methoxyphenyl)-4-[[[3-propyl-4-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]oxy]acetyl]-
2H-1-Benzopyran-3-carboxylic acid,2-oxo-7-[[(4'-propyl[1,1'-biphenyl]-4-yl)carbonyl]oxy]-, propyl ester
Benzoic acid,4-(decyloxy)-, 4'-[(1-methylhexyl)oxy]-3'-nitro[1,1'-biphenyl]-4-yl ester
Benzoic acid,4-(dodecyloxy)-, 4'-[(1-methylhexyl)oxy]-3'-nitro[1,1'-biphenyl]-4-yl ester
Benzoic acid,4-(decyloxy)-,4'-[[(1S)-1-methylheptyl] oxy]-3'-nitro[1,1'-biphenyl]-4-yl ester
4(1H)-Pyrimidinone,5-[(6-methyl-3-pyridinyl)methyl]-2-[3-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]propyl]-
[1,1'-Biphenyl]-4-carboxamide,N-[1-[3-(4-methyl-1-piperazinyl)propyl]-1H-benzimidazol-2-yl]-
[1,1'-Biphenyl]-2-carboxylic acid,5-methyl-4'-[(1R)-1-[(4-methyl-3-nitro-2-pyridinyl)amino]ethyl]-, methylester
Morpholine,4-[[[1-methyl-3-propyl-4-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-pyrazol-5-yl]oxy]acetyl]-
Thiomorpholine,4-[[[1-methyl-3-propyl-4-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-pyrazol-5-yl]oxy]acetyl]-
3-Pyridinecarboxamide,N-[3-[[4-[(dimethylamino)methyl]-2-pyridinyl]oxy]propyl]-, 1-oxide
1H-Pyrazol-5-ol, 4-[1,1'-biphenyl]-4-yl-3-methyl-1-(2-pyridinyl)-