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Benzeneacetic acid, a-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]-,cyclopentyl ester, (aS)- (238750-77-1)

Identification
Name:Benzeneacetic acid, a-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]-,cyclopentyl ester, (aS)-
Synonyms:CHR2797;Tosedostat;
CAS:238750-77-1
Molecular Formula: C21H30N2O6
Molecular Weight: 406.4727
InChI: InChI=1/C21H30N2O6/c1-13(2)12-16(18(24)20(26)23-28)19(25)22-17(14-8-4-3-5-9-14)21(27)29-15-10-6-7-11-15/h3-5,8-9,13,15-18,24,28H,6-7,10-12H2,1-2H3,(H,22,25)(H,23,26)/t16-,17+,18+/m1/s1
Molecular Structure: (C21H30N2O6) CHR2797;Tosedostat;
Properties
Density:1.24
Refractive index:1.566
Biological Activity: Aminopeptidase inhibitor (IC 50 values are 100, 150, 220, > 1000, > 5000, > 10000 and > 30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA 4 hydrolase and MetAP2 respectively). Potently inhibits tumor cell proliferation in a variety of tumor cell lines in vitro and in vivo .
Safety Data
 

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