| Identification | |
| Name: | 1H-Imidazole-4-carboxamide,5-amino-1-b-D-ribofuranosyl- |
| Synonyms: | Imidazole-4-carboxamide,5-amino-1-b-D-ribofuranosyl- (6CI,7CI,8CI);1-Ribosyl-4-carboxamido-5-aminoimidazole;1-b-D-Ribofuranosyl-5-amino-4-imidazolecarboxamide;5-Amino-1-ribosyl-4-imidazolecarboxamide;5-Amino-1-b-D-ribofuranosylimidazole-4-carboxamide;5-Amino-4-imidazolecarboxamide ribofuranoside;5-Amino-4-imidazolecarboxamideriboside;5-Aminoimidazole-4-carboxamide 1-(b-D-ribofuranoside);AIC-Riboside;AICA-Riboside;Acadesine;Arasine;NSC 105823;GP 1-110; |
| CAS: | 2627-69-2 |
| EINECS: | 220-097-5 |
| Molecular Formula: | C9H14N4O5 |
| Molecular Weight: | 258.23126 |
| InChI: | InChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1 |
| Molecular Structure: |  |
| Properties | |
| Melting Point: | 214-215 ºC |
| Density: | 2.06 g/cm3 |
| Refractive index: | 1.821 |
| Water Solubility: | H2O: >10 mg/mL |
| Solubility: | H2O: >10 mg/mL |
| Appearance: | Solid |
| Specification: |
Acadesine , its CAS NO. is 2627-69-2, the synonyms are 5-Amino-1-beta-D-ribofuranosylimidazole-4-carboxamide ; 5-Amino-1-beta-ribofuranosyl-imidazole-4-carboxamide ; 5-Amino-1beta-D-ribofuranosylimidazole-4-carboxyamide ; 5-Amino-4-imidazolecarboxamide ribofuranoside ; 5-Aminoimidazole-4-carboxamide ribonucleoside ; AIC-Riboside ; AICA-riboside ; Acadesinum ; Arasine ; EINECS 220-097-5 ; GP-1-110 ; Imidazole-4-carboxamide, 5-amino-1-beta-D-ribofuranosyl- ; NSC 105823 ; UNII-53IEF47846 . |
| Biological Activity: | Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. |
| Storage Temperature: | −20°C |
| Color: | tan |
| Usage: |
Acadesine (CAS NO.2627-69-2) is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. |
| Safety Data | |
| Hazard Symbols |
Xi: Irritant
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