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2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE (265312-55-8)

Identification
Name:2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
Synonyms:2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE;RYUVIDINE
CAS:265312-55-8
Molecular Formula: C15H13N2O2S
Molecular Weight: 0
InChI: InChI=1/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3
Molecular Structure: (C15H13N2O2S) 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE;RYUVIDINE
Properties
Flash Point: 234.3°C
Boiling Point: 463.8°C at 760 mmHg
Density:1.416g/cm3
Refractive index:1.707
Biological Activity: Cyclin-dependent kinase (cdk) 4 inhibitor (IC 50 = 6.0 μ M at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC 50 > 200 μ M at cdk2/cyclin A). Cytotoxic against a range of human cancer cells (IC 50 values are 0.30, 0.61, 1.08 and 1.21 μ g/mL for HL-60, A549, Col 1 and HepG2 cells respectively).
Flash Point: 234.3°C
Safety Data
 

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