Penfluridol (26864-56-2)

Penfluridol (26864-56-2) is a highly potent, first generation diphenylbutylpiperidine antipsychotic Related to other diphenylbutylpiperidine antipsychotics, pimozide and fluspirilene, penfluridol has an extremely long elimination half-life and its effects last for many days after single oral dose. Its antipsychotic potency, in terms of dose needed to produce comparable effects, is similar to both haloperidol and pimozide. It is only slightly sedative, but often causes extrapyramidal side-effects, such as akathisia, dyskinesiae and pseudo-Parkinsonism. Penfluridol is indicated for antipsychotic treatment of chronic schizophrenia and similar psychotic disorders, it is, however, like most typical antipsychotics, being increasingly replaced by the atypical antipsychotics. Due to its extremely long lasting effects, it is often prescribed to be taken orally as tablets only once a week (q 7 days). The once-weekly dosis is usually 10 — 60 mg.