| Identification |
| Name: | Gedunin |
| Synonyms: | Gedunine;16,17-Seco-24-nor-5alpha,13alpha,14beta,17alpha-chola-1,20,22-trien-16-oic acid, 14,15beta:21,23-diepoxy-7alpha,17-dihydroxy-4,4,8-trimethyl-3-oxo-, 16,17-lactone, acetate (8CI) |
| CAS: | 2753-30-2 |
| Molecular Formula: | C28H34 O7 |
| Molecular Weight: | 0 |
| InChI: | InChI=1/C28H34O7/c1-15(29)33-20-13-18-24(2,3)19(30)8-10-25(18,4)17-7-11-26(5)21(16-9-12-32-14-16)34-23(31)22-28(26,35-22)27(17,20)6/h8-10,12,14,17-18,20-22H,7,11,13H2,1-6H3/t17-,18+,20-,21?,22-,25-,26+,27+,28-/m1/s1 |
| Molecular Structure: |
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| Properties |
| Flash Point: | 313.2°C |
| Boiling Point: | 594.3°Cat760mmHg |
| Density: | 1.28g/cm3 |
| Refractive index: | 1.581 |
| Biological Activity: | Naturally occurring Hsp90 inhibitor. Induces Hsp90-dependent client protein degradation and displays antiproliferative activity in vitro (IC 50 values are 3.22, 8.84 and 16.8 μ M in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Also exhibits antimalarial activity against P. falciparum (IC 50 values are 0.14 and 3.1 μ M in parasite development and [ 3 H]-hypoxanthine uptake assays respectively). |
| Flash Point: | 313.2°C |
| Safety Data |
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