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4(1H)-Quinazolinone,2,3-dihydro-2-(1-naphthalenyl)- (31785-60-1)

Identification
Name:4(1H)-Quinazolinone,2,3-dihydro-2-(1-naphthalenyl)-
Synonyms:4(1H)-Quinazolinone,2,3-dihydro-2-(1-naphthyl)- (8CI);2,3-Dihydro-2-(1-naphthyl)-4(1H)-quinazolinone; NSC 145669; U 29409
CAS:31785-60-1
Molecular Formula: C18H14 N2 O
Molecular Weight: 274.34
InChI: InChI=1/C18H14N2O/c21-18-15-9-3-4-10-17(15)20(12-19-18)16-11-5-7-13-6-1-2-8-14(13)16/h1-11H,12H2,(H,19,21)
Molecular Structure: (C18H14N2O) 4(1H)-Quinazolinone,2,3-dihydro-2-(1-naphthyl)- (8CI);2,3-Dihydro-2-(1-naphthyl)-4(1H)-quinazolinone...
Properties
Flash Point: 294.6°C
Boiling Point: 563.6°Cat760mmHg
Density:1.257g/cm3
Refractive index:1.687
Specification:

A series of derivatives of 2,3-Dihydro-2-(1-naphthyl)-4(1h)-quinazolinone (CAS NO.31785-60-1)  (DHQZ) with known antitumor activity was re-evaluated in the National Cancer Institute cancer cell line screen. Analysis by the COMPARE algorithm suggested that their cytotoxicity derived from interactions with tubulin. Significant inhibition of tubulin assembly and of the binding of radiolabeled colchicine to tubulin was demonstrated with several of the compounds, particularly NSC 145669, 175635, and 175636. The DHQZ derivatives are structurally analogous to a number of antimitotic agents, flavonols and derivatives of 2-styrylquinazolin-4(3H)-one and of 2-phenyl-4-quinolone. Structure-activity analogies between these agents, the combretastatins, and the colchicinoids were analyzed and summarized.

Flash Point: 294.6°C
Safety Data