| Identification | |
| Name: | Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)- |
| Synonyms: | Estra-1,3,5(10)-triene-3,17b-diol, 2-methoxy- (7CI,8CI);Estradiol, 2-methoxy- (6CI);2-Hydroxyestradiol 2-methyl ether;2-Methoxyestra-1,3,5(10)-triene-3,17b-diol;NSC 659853;Panzem; |
| CAS: | 362-07-2 |
| Molecular Formula: | C19H26O3 |
| Molecular Weight: | 302.41 |
| InChI: | InChI=1/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1 |
| Molecular Structure: |  |
| Properties | |
| Transport: | UN 3077 9/PG 3 |
| Flash Point: | 234.7°C |
| Boiling Point: | 464.4°Cat760mmHg |
| Density: | 1.178g/cm3 |
| Refractive index: | 1.586 |
| Solubility: | DMSO: 10 mg/mL |
| Appearance: | Off-white solid |
| Specification: |
2-Methoxyestradiol ,its cas register number is 362-07-2. It also can be called Panzem ; 2-Hydroxyestradol 2-methyl ether ; and 2-Methoxyestradiol-17beta . |
| Biological Activity: | Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly. |
| Flash Point: | 234.7°C |
| Storage Temperature: | −20°C |
| Color: | light yellow |
| Usage: |
2-Methoxyestradiol (CAS.362-07-2) is a natural metabolite which is devoid of estrogenic activity. It is inhibits cell proliferation and angiogenesis. |
| Safety Data | |
| Hazard Symbols |
T: Toxic
|
 |
|
