| Identification | |
| Name: | Vandetanib |
| Synonyms: | 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline; Vandetanib, Zactima, ZD6474 |
| CAS: | 443913-73-3 |
| Molecular Formula: | C22H24BrFN4O2 |
| Molecular Weight: | 475.353963 |
| InChI: | InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) |
| Molecular Structure: | ![(C22H24BrFN4O2) 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline; Vandetanib, Za...](https://img.guidechem.com/casimg/443913-73-3.gif) |
| Properties | |
| Melting Point: | 240-243oC |
| Density: | 1.406 |
| Water Solubility: | Soluble in DMSO |
| Solubility: | Soluble in DMSO |
| Appearance: | White solid |
| Specification: |
? Zactima , with CAS number of 443913-73-3, can be called N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-4-quinazolinamine ; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine ; Vandetanib . It is a?yellow solid,?Zactima (CAS NO.443913-73-3) is a once-daily oral inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor kinase activity. |
| Usage: | Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor kinase activity. The activity of vandetanib plus docetaxel was assessed in patients with previously treated non-small-cel |
| Safety Data | |
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