| Identification | |
| Name: | Pyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoicacid, 1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-,1,1-dimethylethyl ester, (3S,6S,12aS)- |
| Synonyms: | Ko 143 |
| CAS: | 461054-93-3 |
| Molecular Formula: | C26H35 N3 O5 |
| Molecular Weight: | 469.57 |
| Molecular Structure: |  |
| Properties | |
| Melting Point: | 147 oC |
| Density: | 1.24g/cm3 |
| Refractive index: | 1.597 |
| Water Solubility: | Soluble to 100 mM in DMSO and to 100 mM in Ethanol |
| Solubility: | Soluble to 100 mM in DMSO and to 100 mM in Ethanol |
| Biological Activity: | Potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC 90 = 26 nM). Displays > 200-fold selectivity over P-gp and MRP-1 transporters. Increases intracellular drug accumulation and reverses BCRP-mediated multidrug resistance. |
| Safety Data | |
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