| Identification | |
| Synonyms: | 1,3,5-estratriene-3,17beta-diol; 17beta-estradiol; 3,17beta-dihydroxy-1,3,5(10)-estratriene; dihydrofolliculin; ESTRADIOL |
| CAS: | 50-28-2 |
| EINECS: | 200-023-8 |
| Molecular Formula: | C18H24O2 |
| Molecular Weight: | 272.38 |
| InChI: | InChI=1/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 |
| Molecular Structure: |  |
| Properties | |
| Transport: | HAZARD |
| Density: | 1.17g/cm3 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| Refractive index: | 1.599 |
| Water Solubility: | practically insoluble |
| Solubility: | practically insoluble < |
| Appearance: | white to off-white crystalline powder |
| Report: |
NTP 10th Report on Carcinogens.?IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 21 , 1979,p. 279; IMEMDT ?? IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 6 , 1974,p. 99.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.:?) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program. |
| Packinggroup: | III |
| Biological Activity: | Endogenous estrogen receptor (ER) agonist (K i values are 0.12 and 0.13 nM for ER α and ER β respectively). Also high affinity ligand at membrane estrogen GPR30 receptors. |
| Color: | Prisms from 80% alcohol White or slightly yellow, small crystals or crystalline powder |
| Usage: | Potent mammalian estrogenic hormone produced by the ovary. |
| Safety Data | |
| Hazard Symbols |
T:Toxic
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