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Furosemide (54-31-9)

Identification
Name:Furosemide
Synonyms:5-(aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)benzoic acid; 4-chloro-n-furfuryl-5-sulfamoylanthranilic acid; 2-furfurylamino-4-chloro-5-sulfamoylbenzoic acid
CAS:54-31-9
EINECS: 200-203-6
Molecular Formula: C12H11ClN2O5S
Molecular Weight: 330.74414
InChI: InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
Molecular Structure: (C12H11ClN2O5S) 5-(aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)benzoic acid; 4-chloro-n-furfuryl-5-sulfamoylan...
Properties
Transport:UN 1230 3/PG 2
Density:1.606
Stability:Stable, but light sensitive, air sensitive and hygroscopic. Incompatible with strong oxidizing agents.
Water Solubility:Slightly soluble in water
Solubility:Slightly soluble in water
Appearance:white powder
Specification:

 Furosemide may undergo hydrolysis at sufficiently low pH. The pH of aqueous solutions should be maintained in the basic range to prevent hydrolysis. Alcohol has been shown to improve the stability of Furosemide. Incompatible with strong oxidizing agents .

Biological Activity: Loop diuretic that inhibits the Na + /2Cl - /K + (NKCC) cotransporter. Also acts as a non-competitive antagonist at GABA A receptors with ~ 100-fold greater selectivity for α 6-containing receptors than α 1-containing receptors.
Storage Temperature: 2-8°C
Color: Crystals from aqueous ethanol
Yellow powder
FINE, WHITE TO SLIGHTLY YELLOW, CRYSTALLINE POWDER
Usage:Used as a diuretic
Safety Data
Hazard Symbols T:Toxic