| Identification | |
| Name: | Aminopterinum |
| Synonyms: | Aminopterine; Aminopterin; N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid; 4-Aminofolic Acid; 4-amino-4-deoxypteroylglutamate; 4-amino-folicaci; 4-aminofolicacid[qr]; 4-amino-pga[qr]; 4-aminopteroylglutamicacid[qr]; 4-diamino-6-pteridinyl)methyl)amino)benzoyl)-n-(p-(((l-glutamicaci; AGPA; ai3-26079[qr] |
| CAS: | 54-62-6 |
| EINECS: | 200-209-9 |
| Molecular Formula: | C19H20N8O5 |
| Molecular Weight: | 440.41 |
| InChI: | InChI=1/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1 |
| Molecular Structure: | ![(C19H20N8O5) Aminopterine; Aminopterin; N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid; 4...](https://img.guidechem.com/casimg/54-62-6.gif) |
| Properties | |
| Transport: | UN 2811 |
| Flash Point: | °C |
| Boiling Point: | °Cat760mmHg |
| Density: | 1.588g/cm3 |
| Stability: | Stable at normal temperatures and pressures. |
| Refractive index: | 1.761 |
| Alpha: | 18 º (C=1% IN 0.1N NAOH) |
| Water Solubility: | 2 M NaOH: 50 mg/mL |
| Solubility: | 2 M NaOH: 50 mg/mL,Soluble in dilute aqeuous base or DMSO; slightly soluble in water or ethanol. |
| Appearance: | Yellow solid. |
| Specification: |
Aminopterin (54-62-6) also can be called A-Ninopterin ; Aminofolic acid, 4- ; glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]- ; N-[(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}phenyl)carbonyl]glutamic acid . |
| Report: |
EPA Extremely Hazardous Substances List. |
| Packinggroup: | I |
| Flash Point: | °C |
| Storage Temperature: | 2-8°C |
| Color: | yellow |
| Usage: | A folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inh |
| Safety Data | |
| Hazard Symbols |
T+:Verytoxic
|
 |
|
