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2-Propenamide,N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-, (2E)- (545395-94-6)

Identification
Name:2-Propenamide,N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-, (2E)-
Synonyms:(2E)-N-(2H,3H-Benzo[3,4-e]-1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]prop-2-enamide;AMG 9810;
CAS:545395-94-6
Molecular Formula: C21H23NO3
Molecular Weight: 337.41
InChI: InChI=1/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+
Molecular Structure: (C21H23NO3) (2E)-N-(2H,3H-Benzo[3,4-e]-1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]prop-2-enamide;AMG 9810;
Properties
Flash Point: 263.8°C
Boiling Point: 512.5°C at 760 mmHg
Density:1.175g/cm3
Refractive index:1.617
Biological Activity: Potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC 50 = 17 nM). Inhibits capsaicin-, proton-, heat- and endogenous ligand-induced activation of human and rat recombinant TRPV1 receptors. Displays antihyperalgesic properties in a rat model of inflammatory pain.
Flash Point: 263.8°C
Storage Temperature: 2-8°C
Safety Data
 

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