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Tamoxifen citrate (54965-24-1)

Identification
Name:Tamoxifen citrate
Synonyms:Farmifeno;Oncomox;Tamoxifen citrate (JAN/USP);Tafoxen;Kessar;Tamoxasta;Tamoxifenum [INN-Latin];Nolvadex (TN);Soltamox;Noxitem;Oncotam;Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl, (Z)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1);Crisafeno;Nourytan;Tamoplex;Tamofen;ICI 46474;Tamax;Tamoxifene [INN-French];Tamoxen;Nolvadex;Ethanamine,2-[4-[(1Z)-1,2-diphenyl-1- butenyl]phenoxy]-N,N-dimethyl-,2-hydroxy- 1,2,3-propanetricarboxylate (1:1);2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethyl-ethanamine; 2-hydroxypropane-1,2,3-tricarboxylic acid;Valodex;Ethanamine, 2-[4- (1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-, 2-hydroxy-1,2,3-propane-tricarboxylate (1:1);
CAS:54965-24-1
EINECS: 259-415-2
Molecular Formula: C26H29NO.C6H8O7
Molecular Weight: 563.64
InChI: InChI=1/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
Molecular Structure: (C26H29NO.C6H8O7) Farmifeno;Oncomox;Tamoxifen citrate (JAN/USP);Tafoxen;Kessar;Tamoxasta;Tamoxifenum [INN-Latin];Nolva...
Properties
Stability:Stable under normal temperatures and pressures.
Water Solubility:slightly soluble
Solubility:slightly soluble
Appearance:white to off-white powder
Specification:

?Tamoxifen citrate , its cas register number 54965-24-1. It also can be called?(Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethylamine citrate (1:1) ; Apo-Tamox ; Caditam ;
Emblon ; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl, (Z)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) ; Farmifeno ; Genox ; Ginarsan ; ICI 46,474 ; ICI 46474 ; Jenoxifen ; Kessar ; Ledertam ; NSC 180973 ; Nolgen ; Noltam ; Nolvadex ; Nourytan ; Noxitem ; Oncotam ; Soltamox ; TMX ; Tafoxen ; Tamax ; Tamofen ; Tamoplex ; Tamox-Puren ; Tamoxasta ; Tamoxifen citrate ; Taxus ; Terimon ; UNII-7FRV7310N6 ; Z-Tamoxifen citrate ; Zemide ; Zitazonium ; Zynoplex ; and trans-1-(p-beta -Dimethylaminoethoxyphenyl)-1,2-diphenylbut-1-ene citrate .?Its classification code are?Anti-estrogen; Drug / Therapeutic Agent;?Human Data;?Mutation data;?Reproductive Effect and Tumor data.
?Tamoxifen citrate (CAS NO.54965-24-1) could be stable under normal temperatures and pressures. It should avoid the condition like incompatible materials, light, heat. It is not compatible with strong oxidizing agents. And also prevent it to broken down into hazardous decomposition products: Nitrogen oxides, carbon monoxide, carbon dioxide. However, its hazardous polymerization will not occur.

Report:

IARC Cancer Review: Human Sufficient Evidence (Benefits outweigh risk for breast cancer patients. 22 Feb, 1997).

Biological Activity: Estrogen receptor antagonist/partial agonist. Selective and potent inhibitor of mammalian sterol isomerase. Neuroprotective in female rats in vivo . Also high affinity agonist at the membrane estrogen receptor GPR30.
Color: Crystals from petroleum ether.
Usage:

A nonsteroidal antiestrogen. Used for treatemnt of advanced, metastatic breast cancer.

Safety Data
Hazard Symbols T:Toxic
 

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