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Domperidone (57808-66-9)

Identification
Name:Domperidone
Synonyms:5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone;Domperidonum;Motilium;
CAS:57808-66-9
EINECS: 260-968-7
Molecular Formula: C22 H24 Cl N5 O2
Molecular Weight: 425.91126
InChI: InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)
Molecular Structure: (C22H24ClN5O2) 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone;Domperidonum;Mot...
Properties
Melting Point: 242.5 oC
Density:1.341 g/cm3
Stability:Stable. Incompatible with strong oxidizing agents.
Water Solubility:DMSO: >10 mg/mL
Solubility:DMSO: >10 mg/mL
Appearance:white powder
Specification:

? Domperidone (CAS NO.57808-66-9), its Synonyms are 2H-Benzimidazol-2-one, 1,3-dihydro-5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)- ; 2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro- ; 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone ; Domperidonum ; Motilium . It is white powder.

Biological Activity: Peripheral dopamine D 2 -like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED 50 values are 0.003 and 0.03 mg/kg for i.v. and oral administration respectively).
Storage Temperature: Keep tightly closed.
Color: white
Usage:

Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic.

Safety Data
Hazard Symbols Xn:Harmful