| Identification | |
| Name: | clozapine |
| Synonyms: | - |
| CAS: | 5786-21-0 |
| EINECS: | 227-313-7 |
| Molecular Formula: | C18H19ClN4 |
| Molecular Weight: | 326.82326 |
| InChI: | InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3 |
| Molecular Structure: |  |
| Properties | |
| Transport: | UN 2811 6 |
| Density: | 1.31 g/cm3 |
| Stability: | Stable at normal temperatures and pressures. |
| Refractive index: | 1.681 |
| Water Solubility: | ethanol: 1 mg/mL in water |
| Solubility: | ethanol: 1 mg/mL in water |
| Appearance: | a yellow, crystalline powder, very slightly soluble in water |
| Specification: |
?Clozapine , its cas register number is 5786-21-0. It also can be called 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine ; Leponex ; and 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)- .?Many minor though some serious and potentially fatal: the more common include constipation, drooling, muscle stiffness, sedation, tremors, orthostasis, hyperglycemia, and weight gain. Extrapyramidal symptoms may subside somewhat after a person switches from another antipsychotic to clozapine. Clozapine (CAS NO.5786-21-0) also carries black box warnings for seizures, myocarditis, and "other adverse cardiovascular and respiratory effects."?Slow titration of dosing may also decrease the risk for orthostatic hypotension and other adverse cardiovascular side effects. It?may have a synergistic effect with the sedating action of other drugs such as benzodiazepines, and thus respiratory depression may result with concomitant use. Care should be taken, especially if the latter drugs are given parenterally. |
| Packinggroup: | III |
| Biological Activity: | Atypical antipsychotic drug, with a much lower tendency to cause extrapyramidal side effects than conventional neuroleptics. Displays a broad range of pharmacological actions; the antipsychotic effects are thought to be mediated principally by 5-HT 2A/2C and dopamine receptor blockade (K i values are 21, 170, 170, 230 and 330 nM for D 4 , D 3 , D 1 , D 2 and D 5 receptors respectively). |
| Storage Temperature: | Keep tightly closed. |
| Color: | Yellow crystals from acetone-petroleum ether |
| Usage: | An antipsychotic |
| Safety Data | |
| Hazard Symbols |
Xi:Irritant
|
 |
|
