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L-Leucine,N-[(2S,3R)-3-amino-2-hydroxy-1-oxo-4-phenylbutyl]- (58970-76-6)

Identification
Name:L-Leucine,N-[(2S,3R)-3-amino-2-hydroxy-1-oxo-4-phenylbutyl]-
Synonyms:L-Leucine,N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, [S-(R*,S*)]-;(-)-Bestatin;Bestatin;NK 421;NSC 265489;Ubenimex;
CAS:58970-76-6
EINECS: 261-529-2
Molecular Formula: C16H24N2O4
Molecular Weight: 308.38
InChI: InChI=1/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
Molecular Structure: (C16H24N2O4) L-Leucine,N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, [S-(R*,S*)]-;(-)-Bestatin;Bestatin;NK 421;NSC ...
Properties
Density:1.197 g/cm3/sup>
Stability:Stable at normal temperatures and pressures.
Refractive index:1.557
Solubility:Soluble
Appearance:White crystalline powder
Biological Activity: Aminopeptidase inhibitor (K i = 0.001-90 mM); inhibits enkephalin metabolism and leukotriene A 4 hydrolase. Inhibits tumor cell proliferation.
Usage:

An aminopeptidase inhibitor used in combination with chemotherapeutics for the maintenance and enhancement of complete remission of acute non-lymphocytic leukemia in adults.

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