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L-Glutamicacid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (59-05-2)

Identification
Name:L-Glutamicacid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
Synonyms:Glutamicacid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)-(8CI);(+)-Amethopterin;Amethopterin;Amethopterine;Antifolan;CL 14377;EMT 25299;Emtexate;Emthexate PF;L-Amethopterin;L-Methotrexate;Ledertrexate;Metatrexan;Mexate;N-[p-[[2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-(+)-glutamicacid;NSC 740;R 9985;Rheumatrex;Trexall;
CAS:59-05-2
EINECS: 200-413-8
Molecular Formula: C20H22N8O5
Molecular Weight: 454.44
InChI: InChI=1/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m1/s1
Molecular Structure: (C20H22N8O5) Glutamicacid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)-(8CI);(+)-Amethop...
Properties
Transport:UN 1544
Density:1.536 g/cm3
Stability:Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.
Water Solubility:Insoluble.
Appearance:yellow crystalline powder
Specification:

?Methotrexate , its cas register number 59-05-2. It also can be called? 4-Amino-10-methylfolic acid ; 4-Amino-N(sup 10)-methylpteroylglutamic acid ; 4-Aminomethylpteroylglutamic acid ; A-Methopterin ; A-Methpterin ; Abitrexate ; Amethopterin?;?Amethopterin L- ; Antifolan ; Brimexate ; Emtexate ; Emthexat?;?Emthexate ; Farmitrexat ; Fauldexato ; Folex ; Folex PFS ; Folex-Pfs ; Kyselina 4-amino-N(sup 10)-methylpteroylglutamova ; Kyselina 4-amino-N(sup 10)-methylpteroylglutamova [Czech] ; Kyselina N-(p-((2,4-diamino-6-pteridinylmethyl)methylamino)benzoyl)-L-glutamova ; Kyselina N-(p-((2,4-diamino-6-pteridinylmethyl)methylamino)benzoyl)-L-glutamova [Czech] ; L-(+)-N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)glutamic acid ; L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl) ethylamino)benzoyl)- ; Lantarel ; Ledertrexate ; Lumexon ; Maxtrex?;?Metatrexan ; Methoblastin ; Methotrexat-Ebewe ; Methotrexate ; Methotrexate LPF ; Methotrexate, L- ; Methotrexatum ; Methotrexatum [INN-Latin] ; Methylaminopterin ; Methylaminopterinum ; Metotressato ; Metotressato [DCIT] ; Metotrexato ; Metotrexato [INN-Spanish] ; Metrotex ; Mexate ; Mexate-AQ ; N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamicacid ; N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-(+)-glutamic acid ; N-(p-(((2,4-Diamino-6-pteridyl)methyl)methylamino)benzoyl)glutamic acid ; N-Bismethylpteroylglutamic acid ; Novatrex ; Rheumatrex ; Texate ; Tremetex ; Trexeron ; Trixilem ; UNII-YL5FZ2Y5U1 ; and alpha-Methopterin .?
Its classification code are?Abortifacient Agents; Abortifacient agents, nonsteroidal; Agricultural Chemical;?Antimetabolites;?Antimetabolites, antineoplastic; Antineoplastic;?Antineoplastic Agents;?Antirheumatic agents;?Dermatologic agents;?Drug / Therapeutic Agent; Enzyme inhibitors;?Folic acid antagonists;?Human Data; Immunologic Factors;?Immunosuppressive agents;?Insecticide;?Mutation data;?Noxae;?Nucleic acid synthesis inhibitors;?Reproductive Control Agents;?Reproductive Effect;?Skin / Eye Irritant and Tumor data.

Report:

IARC Cancer Review: Group 3 IMEMDT??? IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 241.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT??? IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 ,1981,p. 267.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT??? IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 ,1981,p. 267.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Studies (ipr); No Evidence: mouse, rat CANCAR??? Cancer. 40 (1977),1935. . Reported in EPA TSCA Inventory.

Packinggroup: III
HS Code: 29335995
Biological Activity: Cytotoxic agent. Inhibits thymidylate synthetase and de novo purine synthesis. Potent folic acid antagonist; inhibits dihydrofolate reductase. Also inhibits Ras carboxyl methylation in DKOB8 cells, leading to decreased p44 and Akt activation.
Color: Orange-brown, crystalline powder
Usage:

Used as a antineoplastic and antirheumatic. A folic Acid antagonist

Safety Data
Hazard Symbols T:Toxic
 

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