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9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one,2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-,(9S,10R,11R,13R)- (62996-74-1)

Identification
Name:9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one,2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-,(9S,10R,11R,13R)-
Synonyms:9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one,2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9a,10b,11b,13a)]-;(+)-Staurosporine;AM-2282;Alkaloid AM-2282 from Streptomyces;Antibiotic 230;Antibiotic AM 2282;CGP39360;Staurosporin;Staurosporine;
CAS:62996-74-1
Molecular Formula: C28H26N4O3
Molecular Weight: 466.538
InChI: InChI=1/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
Molecular Structure: (C28H26N4O3) 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one,2,3,10,11,12,1...
Properties
Density:1.56 g/cm3
Appearance:off-white powder
Specification:

The Staurosporine, with CAS registry number 62996-74-1, belongs to the following product categories: (1)All Inhibitors; (2)Inhibitors; (3)Intermediates & Fine Chemicals; (4)Pharmaceuticals; (5)Protein Kinase Inhibitors and Activators; (6)Protein Kinase; (7)Signalling. It has the systematic name of (5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one. This chemical should be stored at the temperature of 2-8°C.

Physical properties of Staurosporine: (1)ACD/LogP: 5.27; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 2.327; (4)ACD/LogD (pH 7.4): 3.713; (5)ACD/BCF (pH 5.5): 6.798; (6)ACD/BCF (pH 7.4): 165.23; (7)ACD/KOC (pH 5.5): 20.016; (8)ACD/KOC (pH 7.4): 486.488; (9)#H bond acceptors: 7; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 69.45 Å2; (13)Index of Refraction: 1.81; (14)Molar Refractivity: 128.823 cm3; (15)Molar Volume: 298.711 cm3; (16)Polarizability: 51.07×10-24cm3; (17)Surface Tension: 62.885 dyne/cm; (18)Enthalpy of Vaporization: 99.457 kJ/mol; (19)Vapour Pressure: 0 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
The Trimesic acid irritates to eyes, respiratory system and skin. This chemical may cause cancer. And it has limited  evidence of a carcinogenic effect. Before using it, please avoid exposure - obtain special instructions before use. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice. 

You can still convert the following datas into molecular structure:
(1)SMILES: C[C@@]12[C@@H]([C@@H](C[C@@H](O1)n3c4ccccc4c5c3c6n2c7ccccc7c6c8c5C(=O)NC8)NC)OC
(2)InChI: InChI=1/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
(3)InChIKey: HKSZLNNOFSGOKW-FYTWVXJKBZ
(4)Std. InChI: InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
(5)Std. InChIKey: HKSZLNNOFSGOKW-FYTWVXJKSA-N

Biological Activity: Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC 50 = 3 nM), protein kinase A (IC 50 = 7 nM), p 60v-src tyrosine protein kinase (IC 50 = 6 nM) and CaM kinase II (IC 50 = 20 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .
Storage Temperature: 2-8°C
Usage:A protein Kinase C inhibitor that induces apoptosis in many cell types
Safety Data
 

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