| Identification | |
| Name: | Nicorandil |
| Synonyms: | 2-Nicotinamidoethylnitrate;Dancor;Ikorel;N-(2-Hydroxyethyl)nicotinamide nitrate;N-(2-Hydroxyethyl)nicotinamide nitrate ester;N-(2-Nitrooxyethyl)nicotinamide;3-Pyridinecarboxamide,N-[2-(nitrooxy)ethyl]-;Perisalol;SG 75;Sigmart;U 64417; |
| CAS: | 65141-46-0 |
| EINECS: | 265-514-1 |
| Molecular Formula: | C8H9N3O4 |
| Molecular Weight: | 211.18 |
| InChI: | InChI=1/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12) |
| Molecular Structure: |  |
| Properties | |
| Density: | 1.331 g/cm3 |
| Refractive index: | 1.547 |
| Appearance: | white or off-white powder |
| Specification: |
?Common side effects include flushing, palpitation, weakness, headache, mouth ulcers, nausea and vomiting. More recently peri-anal, ileal and peri-stomal ulceration has been reported as a side effect. Anal ulceration is now included in the British National Formulary as a reported side effect. It can also give the feeling of severe toothache, and nasal congestion. |
| Biological Activity: | K ATP channel opener and NO donor, clinically used as antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing K ATP channels (EC 50 values are 10 and > 500 mM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning. |
| Usage: | An antianginal |
| Safety Data | |
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