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Acetamide,N-[4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]- (6673-35-4)

Identification
Name:Acetamide,N-[4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-
CAS:6673-35-4
EINECS: 229-712-1
Molecular Formula: C14H22 N2 O3
Molecular Weight: 266.38
InChI: InChI=1/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)/p+1/t13-/m0/s1
Molecular Structure: (C14H22N2O3) Acetanilide,4'-[2-hydroxy-3-(isopropylamino)propoxy]- (7CI,8CI); (?à)-Practolol; 1-(4-Acetamidophen...
Properties
Flash Point: 252.3°C
Boiling Point: 493.6°C at 760 mmHg
Density:1.127 g/cm3
Specification:

  Eraldin (CAS NO.6673-35-4), with the CAS registry number 6673-35-4, is also called 1-(4-Acetamidophenoxy)-3-isopropylamino-2-propanol ; 4'-(2-Hydroxy-3-(isopropylamino)propoxy)acetanilide ; AY 21011 ; Acetamide, N-(4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)- ; CCRIS 1089 ; Dalzic ; ICI 50172 ; N-(4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide ; Practolol ; Practololum [INN-Latin] ; Praktololu [Polish] ; Teranol ; UNII-SUG9176GRW . It is used as cardiovascular system drug.
  Eraldin (CAS NO.6673-35-4) is poison by intravenous route. Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Human systemic effects by ingestion: eye damage, peritonitis, and dermatitis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. And  Its toxic tabulation is:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 7550mg/kg/2Y (7550mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGES IN EXTRA-OCULAR MUSCLES: EYE

GASTROINTESTINAL: PERITONITIS

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 Medical Journal of Australia. Vol. 1, Pg. 44, 1975.
mouse LD50 intraperitoneal 455mg/kg (455mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Polish Journal of Pharmacology and Pharmacy. Vol. 25, Pg. 145, 1973.
mouse LD50 intravenous 67400ug/kg (67.4mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA		 Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 126, 1973.
mouse LD50 oral 3661mg/kg (3661mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 126, 1973.
mouse LD50 subcutaneous 3357mg/kg (3357mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 126, 1973.
rat LD50 intraperitoneal 540mg/kg (540mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 126, 1973.
rat LD50 intravenous 130mg/kg (130mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 126, 1973.
rat LD50 oral 3458mg/kg (3458mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 126, 1973.
rat LD50 subcutaneous 7500mg/kg (7500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 126, 1973.
women TDLo oral 4mg/kg (4mg/kg) SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE		 British Medical Journal. Vol. 1, Pg. 595, 1975.

Report:

EPA Genetic Toxicology Program.

Flash Point: 252.3°C
Safety Data
 

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