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Fenoldopam (67227-56-9)

Identification
Name:Fenoldopam
CAS:67227-56-9
EINECS: 266-612-7
Molecular Formula: C16H16ClNO3
Molecular Weight: 305.75614
InChI: InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2
Molecular Structure: (C16H16ClNO3) (?à)-Fenoldopam; (?à)-SKF 82526; Fenoldopam; SKF82526
Properties
Density:1.38 g/cm3
Water Solubility:DMSO: >12 mg/mL
Solubility:DMSO: >12 mg/mL
Specification:

   Fenoldopam mesylate (CAS NO.67227-56-9) is a synthetic benzazepine derivative drug that acts as a selective peripheral dopamine D1 receptor weak partial agonist.And it is used as an antihypertensive agent postoperatively, and via IV to treat hypertensive crisis, and also can be called Corlopam ; 6-Chloro-7,8-dihydroxy-1-p-hydroxyphenyl-2,3,4,5-tetrahydro-1H-3-benzazepine ; 1H-3-benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)- ;and 6-Chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol .By activating peripheral D1 receptors, it causes arterial/arteriolar vasodilation leading to a decrease in blood pressure.Adverse effects include flushing, headache, hypotension, reflex tachycardia, angina, and increased intraocular pressure.
  Fenoldopam mesylate (CAS NO.67227-56-9) is irritating to the eyes, so if it is in case of contact with eyes, rinse immediately with plenty of water and seek medical advice; It is may cause sensitization by inhalation and by skin contact, so  people must Wear suitable protective clothing ,suitable gloves and eye/face protection.

Biological Activity: Selective D 1 -like dopamine receptor partial agonist (EC 50 = 57 nM). Vasodilator in vivo and does not readily cross the blood-brain barrier. Also α 2 -adrenoceptor antagonist in vitro (K i = 15-25 nM).
Storage Temperature: 2-8°C
Color: off-white
Safety Data
Hazard Symbols Xn:Harmful