| Identification | |
| Name: | Mevastatin |
| CAS: | 73573-88-3 |
| Molecular Formula: | C23H34O5 |
| Molecular Weight: | 390.51306 |
| InChI: | InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1 |
| Molecular Structure: |  |
| Properties | |
| Density: | 1.13 g/cm3 |
| Refractive index: | 1.528 |
| Water Solubility: | DMSO: 20 mg/mL |
| Solubility: | DMSO: 20 mg/mL |
| Appearance: | white powder |
| Specification: | Off-White Solid usageEng:A fungal metabolite which is a potent inhibitor of HMG-CoA reductase. Safety Statements:22-24/25-45-36/37/39 22:Do not breathe dust 24/25:Avoid contact with skin and eyes 45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 36/37/39:Wear suitable protective clothing, gloves and eye/face protection |
| Biological Activity: | Inhibitor of HMG-CoA reductase; decreases cholesterol biosynthesis, in vitro and in vivo . Induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27. |
| Color: | white |
| Usage: | A fungal metabolite which is a potent inhibitor of HMG-CoA reductase. |
| Safety Data | |
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