| Identification | |
| Name: | Urea,N-ethyl-N-nitroso- |
| Synonyms: | Urea,1-ethyl-1-nitroso- (7CI,8CI); 1-Ethyl-1-nitrosourea; ENU;N-Ethyl-N-nitrosourea; N-Nitroso-N-ethylurea; NSC 45403 |
| CAS: | 759-73-9 |
| EINECS: | 212-072-2 |
| Molecular Formula: | C3H7 N3 O2 |
| Molecular Weight: | 117.13 |
| InChI: | InChI=1/C3H7N3O2/c1-2-6(5-8)3(4)7/h2H2,1H3,(H2,4,7) |
| Molecular Structure: |  |
| Properties | |
| Transport: | UN 2811 6.1/PG 3 |
| Melting Point: | 103-1040C (dec) |
| Flash Point: | 63.8°C |
| Boiling Point: | 181.8°C at 760 mmHg |
| Density: | 1.35g/cm3 |
| Stability: | Unstable at RT, Contains approximately 40% Water, 2.0% Acetic Acid to stabilize |
| Refractive index: | 1.532 |
| Solubility: | SOL IN WATER (APPROX 1.3%) & IN POLAR ORG SOLVENTS; INSOL IN NON-POLAR ORG SOLVENTS Soluble in chloroform. |
| Specification: |
N-Ethyl-N-nitrosourea is a highly potent mutagen. For a given gene in mice, ENU can induce 1 new mutation in every 700 gametes. It is also toxic at high doses.The chemical is an alkylating agent, and acts by transferring the ethyl group of ENU to nucleobases (usually thymine) in nucleic acids. Its main targets are the spermatogonial stem cells, from which mature sperm are derived. |
| Report: |
NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 (1978),p. 191.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 (1978),p. 191.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 1 (1972),p. 135.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program. Community Right-To-Know List. Reported in EPA TSCA Inventory. |
| Packinggroup: | III |
| Flash Point: | 63.8°C |
| Storage Temperature: | −20°C |
| Color: | YELLOW-PINK CRYSTALS Pale buff-yellow hexagonal plates. |
| Usage: | Precursor of Diazoethane |
| Safety Data | |
 |
|
