| Identification | |
| Name: | Camptothecine |
| Synonyms: | 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (+)-Camptothecin; Camptothecin, Camptotheca acuminata; 4-Ethyl-4-hydroxy-1H-pyrano-[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Camptothecin,95%; Camptothecin; 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Camptothecin |
| CAS: | 7689-03-4 |
| EINECS: | 444-280-6 |
| Molecular Formula: | C20H16N2O4 |
| Molecular Weight: | 348.36 |
| InChI: | InChI=1/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1 |
| Molecular Structure: | ![(C20H16N2O4) 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (+)-Camptothec...](https://img.guidechem.com/casimg/7689-03-4.gif) |
| Properties | |
| Transport: | UN 1544 |
| Density: | 1.51 g/cm3 |
| Refractive index: | 1.787 |
| Water Solubility: | insoluble |
| Solubility: | insoluble in water,chloroform/methanol (4:1): 4 mg/mL |
| Appearance: | light yellow crystal powde |
| Specification: |
Camptothecine , its cas register number is 7689-03-4. It also can be called (+)-Camptothecin ; 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione . |
| Biological Activity: | Cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor. |
| Storage Temperature: | 2-8°C |
| Color: | yellow |
| Usage: | Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent |
| Safety Data | |
| Hazard Symbols |
T:Toxic
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