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Luteinizinghormone-releasing factor (swine), 6-[3-(2-naphthalenyl)-D-alanine]- (76932-56-4)

Identification
Name:Luteinizinghormone-releasing factor (swine), 6-[3-(2-naphthalenyl)-D-alanine]-
Synonyms:(D-2-Nal6)-LHRH;Luteinizinghormone-releasing factor (pig), 6-[3-(2-naphthalenyl)-D-alanine]-;NAG;Nafareline;[6-D-(2-naphthyl)-alanine]LH-RH;
CAS:76932-56-4
Molecular Formula: C66H83N17O13
Molecular Weight: 1322.48
InChI: InChI=1/C66H83N17O13/c1-36(2)25-48(58(89)76-47(13-7-23-71-66(68)69)65(96)83-24-8-14-54(83)64(95)73-33-55(67)86)77-60(91)50(28-38-15-18-39-9-3-4-10-40(39)26-38)78-59(90)49(27-37-16-19-43(85)20-17-37)79-63(94)53(34-84)82-61(92)51(29-41-31-72-45-12-6-5-11-44(41)45)80-62(93)52(30-42-32-70-35-74-42)81-57(88)46-21-22-56(87)75-46/h3-6,9-12,15-20,26,31-32,35-36,46-54,72,84-85H,7-8,13-14,21-25,27-30,33-34H2,1-2H3,(H2,67,86)(H,70,74)(H,73,95)(H,75,87)(H,76,89)(H,77,91)(H,78,90)(H,79,94)(H,80,93)(H,81,88)(H,82,92)(H4,68,69,71)
Molecular Structure: (C66H83N17O13) (D-2-Nal6)-LHRH;Luteinizinghormone-releasing factor (pig), 6-[3-(2-naphthalenyl)-D-alanine]-;NAG;Naf...
Properties
Density:1.49 g/cm3
Appearance:White or almost white lyophilized powder
Specification:

The chemical synonyms of Nafarelin (76932-56-4) are 6-(3-(2-Naphthalenyl)-d-alanine)-luteinizinghormone-releasingfactor(pig) ; 6-(3-(2-Naphthalenyl)-d-alanine)luteinizinghormone-releasingfactor(pig) ; ala(2-Naphthyl)(6)-lhr ; Pyr-His-trp-ser-tyr-d-2-nal-leu-arg-pro-gly-nh2;nafarelin ; and (D-2-NAL6)-LHRH;NAFARELIN 98.0+% .
 Nafarelin (CAS NO.76932-56-4) is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estrogen/progesterone. When administered, Nafarelin has the purpose of causing increase estrogen that will negatively feed back upon hypothalamus to decrease GnRH ( negative feedback loop ) Through negative feedback, Nafarelin causes a decrease in pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH).

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