| Identification |
| Name: | 2(3H)-Furanone,4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-,(3R,4R)- |
| Synonyms: | 2(3H)-Furanone,4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-,(3R-trans)-;Arctigenin; |
| CAS: | 7770-78-7 |
| Molecular Formula: | C21H24O6 |
| Molecular Weight: | 372.41 |
| InChI: | InChI=1/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3/t15-,16+/m0/s1 |
| Molecular Structure: |
![(C21H24O6) 2(3H)-Furanone,4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-,(3R-tra...](https://img.guidechem.com/casimg/7770-78-7.gif) |
| Properties |
| Density: | 1.227g/cm3 |
| Refractive index: | 1.576 |
| Solubility: | DMSO: 34 mg/mL with heating and sonicating, soluble in water |
| Biological Activity: | Antioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of I κ B α phosphorylation and p65 nuclear translocation (IC 50 = 10 nM). Inhibits HIV-1 replication in vitro . Also potently inhibits MKK1 (IC 50 = 0.5 nM) and provides neuroprotection by binding to kainate receptors. |
| Safety Data |
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