4H-Pyrimido[6,1-a]isoquinolin-4-one,2,3,6,7-tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-,hydrochloride (1:1) (78416-81-6)

Identification
Name:	4H-Pyrimido[6,1-a]isoquinolin-4-one,2,3,6,7-tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-,hydrochloride (1:1)
Synonyms:	4H-Pyrimido[6,1-a]isoquinolin-4-one,2,3,6,7-tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-,monohydrochloride (9CI); HL 725; Trequinsin hydrochloride
CAS:	78416-81-6
Molecular Formula:	C24H27 N3 O3 . Cl H
Molecular Weight:	441.95
InChI:	InChI=1/C24H27N3O3.ClH/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4;/h9-13H,7-8H2,1-6H3;1H/b25-22-;
Molecular Structure:
Properties
Flash Point:	325°C
Boiling Point:	613.8°C at 760 mmHg
Biological Activity:	Extremely potent inhibitor of cGMP-inhibited phosphodiesterase (PDE3; IC 50 = 250 pM). Potently inhibits arachidonic acid-induced aggregation of human platelets (IC 50 = 50 pM). Orally active antihypertensive agent; reduces systemic blood pressure in both normotensive and hypertensive animal models.
Flash Point:	325°C
Storage Temperature:	Desiccate at RT
Safety Data