| Identification |
| Name: | DCPIB |
| Synonyms: | DCPIB;4-[(2-BUTYL-6,7-DICHLORO-2-CYCLOPENTYL-2,3-DIHYDRO-1-OXO-1H-INDEN-5-YL)OXY]BUTANOIC ACID;4-(2-BUTYL-6,7-DICHLORO-2-CYCLOPENTYLINDAN-1-ON-5-YL)OXYBUTYRIC ACID |
| CAS: | 82749-70-0 |
| Molecular Formula: | C22H28Cl2O4 |
| Molecular Weight: | 427.36 |
| InChI: | InChI=1/C22H28Cl2O4/c1-2-3-10-22(15-7-4-5-8-15)13-14-12-16(28-11-6-9-17(25)26)19(23)20(24)18(14)21(22)27/h12,15H,2-11,13H2,1H3,(H,25,26) |
| Molecular Structure: |
![(C22H28Cl2O4) DCPIB;4-[(2-BUTYL-6,7-DICHLORO-2-CYCLOPENTYL-2,3-DIHYDRO-1-OXO-1H-INDEN-5-YL)OXY]BUTANOIC ACID;4-(2-...](https://img.guidechem.com/structure/82749-70-0.gif) |
| Properties |
| Flash Point: | 312.94°C |
| Boiling Point: | 593.835°C at 760 mmHg |
| Density: | 1.263g/cm3 |
| Refractive index: | 1.564 |
| Biological Activity: | Potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β -cells (IC 50 ~ 2 μ M) and I Cl,swell in various cardiovascular tissues (IC 50 = 4.1 μ M in CPAE cells); blockade is voltage-independent. Displays minimal inhibition of other Cl - and K + currents (< 10% inhibition at 10 μ M). Inhibits glucose-stimulated insulin secretion in intact β -cells via VSAC inhibition and indirect K ATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro . |
| Flash Point: | 312.94°C |
| Safety Data |
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